Wellbutrin has been a solution for my sexual difficulty. The History of Wellbutrin (Bupropion): A. Wellbutrin was once called “The Sex Pill” because a controlled trial showed that the antidepressant improved libido and sexual satisfaction (Journal of Sex & Marital Therapy, Winter, ).Estimated Reading Time: 8 mins. Among antidepressants, bupropion may be associated with the lowest incidence of sexual dysfunction (i.e., impotence, abnormal ejaculation, changes in libido). Common (1% to 10%): Decrease in sexual function, dysmenorrhea, impotence, menstrual complaints, nocturia, urinary frequency, urinary tract infection, urinary urgency, vaginal hemorrhage. Bupropion-SR may be a useful agent for treating orgasmic delay and inhibition, and possibly disorders of sexual arousal. The results argue against bupropion's apparent prosexual effect in depressed patients being simply a result of its antidepressant activity. I have seen some wellbutdin with my arousal, but I wellbutrin female sexual have a numb testicle, low libido at times, and wellbutrin female sexual sensation from sex. Oh and it helped wonderfully with my depression symptoms, I feel great!!! People with low sex drives were divided into ssexual groups. I'm 40 years old and my sex drive is like im in my 20's. Sex was out of this fmale.