Poppers are liquid amyl nitrites and a common uses inhalant chemical psychoactive sex drugs. Second, poppers are used to intensify sexual pleasure, euphoric effects, for stamina or to loosen inhibitions. Also, relaxing the anal muscles. Poppers typically are taken as Estimated Reading Time: 7 mins. Poppers are not gay drugs, as may be the notion out there, but many gay guys use poppers during sex. Gay men mainly prefer poppers because they help loosen up the anal sphincter muscle, making anal sexual experiences easier. Genuine poppers always have a logo embossed on the cap and the bottom of the popper shambhalafundacion.orgted Reading Time: 4 mins. In definition, poppers are substance, which are before or during sex to make it enjoyable. In most, if not all cases, poppers are inhaled. This enhances their distribution in the body, since the nasal region connects directly with the blood stream in the alveoli.